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March 3, 2003CirculationOpen Access

No Evidence of Association Between Prothrombotic Gene Polymorphisms and the Development of Acute Myocardial Infarction at a Young Age

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Why the study?

Do prothrombotic gene polymorphisms increase the risk of premature myocardial infarction in young patients?

Population

2,420 subjects, comprising 1,210 patients who survived a first myocardial infarction at age <45 years and…

Comparison

Presence of 9 polymorphisms of genes encoding… vs Healthy subjects matched for age, sex, and…

Design

Case-control

Discussion

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Overview

These polymorphisms were not associated with premature MI risk; leaves open contributions from other genetic or environmental factors in young adults.

Key Points

  • To determine whether nine genetic polymorphisms involved in hemostasis and thrombosis are associated with the risk of acute myocardial infarction in young adults.
  • Nationwide case-control study involving 1210 patients under age 45 who survived a first myocardial infarction and underwent coronary arteriography across 125 coronary care units.
  • Included 1210 healthy control participants matched for age, sex, and geographical origin.
  • Analyzed 9 polymorphisms related to coagulation factors, platelet function, fibrinolysis, and homocysteine metabolism.
  • No coagulation polymorphisms were associated with myocardial infarction: beta-fibrinogen G-455A (OR 1.0, 95% CI 0.8–1.2), factor V G1691A (OR 1.1, 95% CI 0.6–2.1), factor II G20210A (OR 1.0, 95% CI 0.5–1.9), and factor VII G10976A (OR 1.0, 95% CI 0.8–1.3).
  • No association was found for platelet function (glycoprotein Ia C807T: OR 1.1, 95% CI 0.9–1.3; glycoprotein IIIa C1565T: OR 0.9, 95% CI 0.8–1.2), fibrinolysis (factor XIII G185T: OR 1.2, 95% CI 0.9–1.6; PAI-1 4G/5G: OR 0.9, 95% CI 0.7–1.2), or homocysteine metabolism (MTHFR C677T: OR 0.9, 95% CI 0.8–1.1).

Structured PICO

Do prothrombotic gene polymorphisms increase the risk of premature myocardial infarction in young patients?

P
Population
2,420 subjects, comprising 1,210 patients who survived a first myocardial infarction at age <45 years and underwent coronary arteriography across 125 coronary care units, and 1,210 healthy subjects matched for age, sex, and geographical origin.
I
Intervention
Presence of 9 polymorphisms of genes encoding hemostasis factors (G-455A beta-fibrinogen, G1691A factor V, G20210A factor II, G10976A factor VII, C807T glycoprotein Ia, C1565T glycoprotein IIIa, G185T factor XIII, 4G/5G plasminogen activator inhibitor type 1, C677T methylenetetrahydrofolate reductase).
C
Comparator
Healthy subjects matched for age, sex, and geographical origin.
O
Outcome
Occurrence of premature myocardial infarction.hard clinical

There is no evidence that 9 common prothrombotic gene polymorphisms are associated with the development of premature myocardial infarction in young patients.

Cite This Study

A 2003 study studied this question.

synapsesocial.com/papers/6a82ff17c0477142e551a6cfhttps://doi.org/10.1161/01.cir.0000051465.94572.d0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Polymorphism of a Platelet Glycoprotein Receptor as an Inherited Risk Factor for Coronary Thrombosis1996 · 692 citations
  2. 2Hemostatic Risk Factors and Arterial Thrombotic Disease2001 · 130 citations
  3. 3A common genetic polymorphism associated with lower coagulation factor VII levels in healthy individuals.1991 · 279 citations
  4. 4Prothrombotic Genetic Risk Factors in Young Survivors of Myocardial Infarction1999 · 225 citations
  5. 5Analysis of Platelet Glycoprotein Ia (α2 Integrin) Allele Frequencies in Three North American Populations Reveals Genetic Association between Nucleotide 807C/T and Amino Acid 505 Glu/Lys (HPA-5) Dimorphisms1998 · 27 citations