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January 1, 2008Saudi Medical Journal

Thrombophilia in young patients with acute myocardial infarction

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Why the study?

Do thrombophilic mutations increase the risk of myocardial infarction in patients under 45 years of age?

Population

236 subjects under the age of 45 years, including 129 patients with myocardial infarction and 107 control…

Comparison

Presence of thrombophilic mutations vs Control subjects without myocardial infarction

Design

Case-control

Authors

MÇMurat ÇelikPsychiatric Association of TurkeyAAAbdullah AltıntaşAnkara Sosyal Bilimler ÜniversitesiYÇYusuf ÇelikBiruni University

Discussion

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Implication

Thrombophilic mutations should not yet prompt testing in young MI; supports prioritizing traditional risks while leaving other genetic contributions open.

Structured PICO

Do thrombophilic mutations increase the risk of myocardial infarction in patients under 45 years of age?

P
Population
236 subjects under the age of 45 years, including 129 patients with myocardial infarction and 107 control subjects.
I
Intervention
Presence of thrombophilic mutations (protein C, S, antithrombin III deficiencies, factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations)
C
Comparator
Control subjects without myocardial infarction
O
Outcome
Association of thrombophilia with coronary artery disease (myocardial infarction)hard clinical

Traditional risk factors, rather than thrombophilic mutations, are the primary drivers of myocardial infarction in patients under 45 years of age.

Cite This Study

Çelik et al. (2008) studied this question.

synapsesocial.com/papers/6a19b722443d3ecd7cdeed8bhttps://doi.org/10.15537/1658-3175.4188
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1No Evidence of Association Between Prothrombotic Gene Polymorphisms and the Development of Acute Myocardial Infarction at a Young Age2003 · 193 citations
  2. 2A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis1996 · 3,130 citations
  3. 3Protein C deficiency manifesting as an acute myocardial infarction and ischaemic stroke2003 · 34 citations
  4. 4Homocysteine and Risk of Ischemic Heart Disease and Stroke2002 · 2,079 citations