Key result
The prevalence of heterozygous and homozygous FVL G1691A and MTHFR C677T gene polymorphisms was significantly higher in patients with myocardial infarction compared to healthy controls.
Why the study?
Is there a higher prevalence of FVL G1691A and MTHFR C677T gene polymorphisms in patients with myocardial infarction compared to healthy controls?
Population
45 individuals, comprising 30 patients who survived their first myocardial infarction and 15 healthy…
Comparison
Assessment of Factor V Leiden G1691A and MTHFR… vs Healthy volunteers
Design
Case-control
Authors
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May indicate elevated genetic risk in Egyptian MI patients; hypothesis-generating and should not yet change practice.
Case-Control (n=45)
Is there a higher prevalence of FVL G1691A and MTHFR C677T gene polymorphisms in patients with myocardial infarction compared to healthy controls?
FVL G1691A and MTHFR C677T gene polymorphisms are significantly associated with myocardial infarction in the Egyptian population, suggesting a role as genetic risk factors.
Ezzat et al. (2014) conducted a case-control in Myocardial infarction (n=45). Thrombophilic gene polymorphisms (FVL G1691A and MTHFR C677T) vs. Healthy volunteers (no myocardial infarction) was evaluated on Prevalence of FVL G1691A and MTHFR C677T genotypes. The prevalence of heterozygous and homozygous FVL G1691A and MTHFR C677T gene polymorphisms was significantly higher in patients with myocardial infarction compared to healthy controls.
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