What does this research mean for the field?

Polymorphisms in the MTHFR (C677T and A1298C), prothrombin (G20210A), and factor V (A4070G) genes are not significantly associated with coronary artery disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 18, 2008Genetics and Molecular BiologyOpen Access

MTHFR , prothrombin and Factor V gene variants in Turkish patients with coronary artery stenosis

Q: What is the clinical evidence from this study?

Study design: Case-Control. Population: Coronary artery disease (n=174). Intervention: MTHFR (C677T and A1298C), prothrombin (G20210A), and factor V (A4070G) gene polymorphisms vs. Healthy controls with grade 0 vessel disease. Primary outcome: Coronary artery disease.

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Key result

MTHFR, prothrombin, and factor V polymorphisms show no association with CAD.

n=174

Why the study?

Are polymorphisms in the MTHFR, prothrombin, and factor V genes associated with coronary artery disease in Turkish patients?

Population

174 Turkish subjects who had undergone coronary angiography, including 115 patients with significant…

Comparison

Polymorphisms in the methylenetetrahydrofolate… vs Absence of these genetic polymorphisms (wild-type)

Design

Case-control

Authors

MCMüge Caner RBRıfat BircanTekirdağ Namık Kemal University DSDeniz Sevinç

Discussion

Member takes

Implication

May not support routine screening for these variants in CAD; leaves open validation in larger prospective cohorts.

Study Design

Type

Case-Control (n=174)

Structured PICO

Are polymorphisms in the MTHFR, prothrombin, and factor V genes associated with coronary artery disease in Turkish patients?

Population

174 Turkish subjects who underwent coronary angiography, comprising 115 patients with significant coronary stenosis and 59 healthy controls.

Exposure

Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), prothrombin (G20210A), and factor V (A4070G) genes

Comparator

Absence of these genetic polymorphisms (wild-type)

Outcome

Association with coronary artery disease (CAD)

Polymorphisms in MTHFR, prothrombin, and factor V genes were not found to be significantly associated with coronary artery disease in this Turkish cohort.

Cite This Study

Caner et al. (2008) conducted a case-control in Coronary artery disease (n=174). MTHFR (C677T and A1298C), prothrombin (G20210A), and factor V (A4070G) gene polymorphisms vs. Healthy controls with grade 0 vessel disease was evaluated on Coronary artery disease. Polymorphisms in the MTHFR, prothrombin, and factor V genes showed no statistically significant association with coronary artery disease.

synapsesocial.com/papers/6aa8fc5cff43606bee5d4904 https://doi.org/10.1590/s1415-47572008005000023

Topics

Coronary artery disease

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November 18, 2008Genetics and Molecular BiologyOpen Access

MTHFR , prothrombin and Factor V gene variants in Turkish patients with coronary artery stenosis

View Full Paper

Ask AI

Bookmark

Key result

MTHFR, prothrombin, and factor V polymorphisms show no association with CAD.

n=174

Why the study?

Are polymorphisms in the MTHFR, prothrombin, and factor V genes associated with coronary artery disease in Turkish patients?

Population

174 Turkish subjects who had undergone coronary angiography, including 115 patients with significant…

Comparison

Polymorphisms in the methylenetetrahydrofolate… vs Absence of these genetic polymorphisms (wild-type)

Design

Case-control

Authors

MCMüge Caner RBRıfat BircanTekirdağ Namık Kemal University DSDeniz Sevinç

Discussion

Member takes

Implication

May not support routine screening for these variants in CAD; leaves open validation in larger prospective cohorts.

Study Design

Type

Case-Control (n=174)

Structured PICO

Are polymorphisms in the MTHFR, prothrombin, and factor V genes associated with coronary artery disease in Turkish patients?

Population

174 Turkish subjects who underwent coronary angiography, comprising 115 patients with significant coronary stenosis and 59 healthy controls.

Exposure

Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), prothrombin (G20210A), and factor V (A4070G) genes

Comparator

Absence of these genetic polymorphisms (wild-type)

Outcome

Association with coronary artery disease (CAD)

Polymorphisms in MTHFR, prothrombin, and factor V genes were not found to be significantly associated with coronary artery disease in this Turkish cohort.

Cite This Study

synapsesocial.com/papers/6aa8fc5cff43606bee5d4904 https://doi.org/10.1590/s1415-47572008005000023

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Coronary artery disease

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