Why the study?
Are factor V Leiden, prothrombin G20120A, MTHFR, factor XIII, and Apo E polymorphisms associated with the development of coronary artery disease?
Are factor V Leiden, prothrombin G20120A, MTHFR, factor XIII, and Apo E polymorphisms associated with the development of coronary artery disease?
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This study evaluates the association between multiple genetic polymorphisms and the presence of angiographically proven coronary artery disease.
Objectives: The aim of our study was to evaluate the possible roles of factor V Leiden, prothrombin G20120A mutations, factor XIIIA and B, methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C and apolipoprotein (Apo) E polymorphisms in the development of coronary artery disease (CAD). Methods: A total of 442 subjects (234 CAD and 208 non-CAD) were included in the study according to their coronary angiography. Polymerase chain reaction (PCR), real-time PCR and restriction enzyme analysis (REA) were carried out in the study.
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Yenilmez et al. (2012) studied this question.
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