Key result
Pairing unfavourable genotypes (e.g., Leiden V, ACE D/D, APO e4) with clinical risk factors like hypertension, diabetes, smoking, or drinking synergistically increases ischaemic stroke risk.
Why the study?
Do common unfavorable genetic mutations interact with clinical risk factors to increase the risk of ischemic stroke?
Population
867 ischaemic stroke patients and 743 healthy controls
Comparison
Presence of common genetic mutations and… vs Healthy controls / absence of these mutations…
Design
Case-control
Authors
Loading...
Supports gene-clinical risk synergy for ischaemic stroke prevention; leaves open whether genotyping improves stratification.
Case-Control (n=1,610)
Do common unfavorable genetic mutations interact with clinical risk factors to increase the risk of ischemic stroke?
Common unfavorable genetic factors, which alone confer minor risk, can greatly increase susceptibility to ischemic stroke when paired with clinical risk factors like hypertension, diabetes, smoking, or drinking.
Zoltán Szolnoki (2003) conducted a case-control in Ischaemic stroke (n=1,610). Unfavourable genotypes and clinical risk factors vs. Healthy controls was evaluated on Ischaemic stroke. Pairing unfavourable genotypes (e.g., Leiden V, ACE D/D, APO e4) with clinical risk factors like hypertension, diabetes, smoking, or drinking synergistically increases ischaemic stroke risk.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: