Why the study?
Do prothrombotic polymorphisms and atherogenic factors synergistically increase the risk of myocardial infarction in young males?
Population
299 young males, including 112 with first acute myocardial infarction before age 52 and 187 healthy controls…
Comparison
Presence of prothrombotic polymorphisms and… vs Absence of these polymorphisms and risk factors
Design
Case-control
Authors
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Supports gene-smoking synergy for premature AMI in young males; hypothesis-generating and requires prospective validation before clinical use.
Do prothrombotic polymorphisms and atherogenic factors synergistically increase the risk of myocardial infarction in young males?
There is a strong synergistic effect between prothrombotic polymorphisms, Apo E4, and traditional atherogenic risk factors like smoking in increasing the risk of premature myocardial infarction in young males.
Inbal et al. (1999) studied this question.
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