Key result
Prothrombic mutations (FV Leiden, prothrombin G20210A, MTHFR C677T) were not associated with left ventricular thrombus, showing similar allele frequencies in patients with vs without thrombus (p≥0.74).
Why the study?
Does the presence of thrombophilic mutations (FV Leiden, prothrombin G20210A, MTHFR C677T) increase the risk of left ventricular thrombus in patients with acute myocardial infarction?
Population
183 consecutive patients with a first anterior acute myocardial infarction, mean age 58 +/- 12 years, 34…
Comparison
Presence of thrombophilic mutations vs Absence of these thrombophilic mutations
Design
Cohort
Follow-up
30 days
Authors
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Does not support thrombophilia screening to predict LV thrombus after anterior MI; leaves open contributions of other factors.
Observational (n=183)
Does the presence of thrombophilic mutations (FV Leiden, prothrombin G20210A, MTHFR C677T) increase the risk of left ventricular thrombus in patients with acute myocardial infarction?
Common thrombophilic mutations (FV Leiden, prothrombin G20210A, MTHFR C677T) are not associated with an increased risk of developing a left ventricular thrombus following an anterior acute myocardial infarction.
Uçar et al. (2004) conducted an observational in First anterior acute myocardial infarction (n=183). Prothrombic mutations (FV Leiden G1691A, prothrombin G20210A, MTHFR C677T) vs. Absence of mutations was evaluated on Left ventricular thrombus. Prothrombic mutations (FV Leiden, prothrombin G20210A, MTHFR C677T) were not associated with left ventricular thrombus, showing similar allele frequencies in patients with vs without thrombus (p≥0.74).
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