Key result
Factor V Leiden and 20210 A prothrombin mutations are not major risk factors for myocardial infarction or stroke unless accompanied by classical risk factors.
Population
Patients with thrombophilia or genetic risk factors
Design
Review
Authors
Discussion
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Member takes
Implication
Classical risks should guide MI/stroke prevention over routine thrombophilia testing; leaves open synergistic effects needing prospective confirmation.
Structured PICO
P
Population
Patients with thrombophilia or genetic risk factors (Factor V Leiden, 20210 A prothrombin mutation, MTHFR mutation)
Genetic thrombophilia mutations (Factor V Leiden, prothrombin 20210A) require classical risk factors to significantly increase the risk of arterial thrombosis, and MTHFR is not a major risk factor for venous thrombosis.
Cite This Study
Huisman et al. (1999) conducted a review in Thrombophilia. Genetic risk factors (Factor V Leiden, 20210 A prothrombin mutation, MTHFR) was evaluated. Factor V Leiden and 20210 A prothrombin mutations are not major risk factors for myocardial infarction or stroke unless accompanied by classical risk factors.