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January 1, 2004Japanese Heart JournalOpen Access

Prothrombin 20210GA and Factor V Leiden Mutations in Patients Less Than 55 Years Old With Myocardial Infarction

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Why the study?

Are prothrombin 20210GA and factor V Leiden mutations significant risk factors for the development of myocardial infarction in patients less than 55 years old?

Population

173 subjects from Southern Turkey, comprising 96 patients with acute myocardial infarction aged less than 55…

Comparison

Presence of prothrombin 20210GA and factor V… vs Absence of mutations / control subjects without…

Design

Case-control

Authors

YDYurdaer DönmezInstitute of CardiologyMKMehmet KanadaşıClinical Trial InvestigatorsKTKahraman TanrıverdiVanderbilt University

Discussion

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Implication

No association with early AMI in this cohort; leaves open roles of these mutations in other populations.

Structured PICO

Are prothrombin 20210GA and factor V Leiden mutations significant risk factors for the development of myocardial infarction in patients less than 55 years old?

P
Population
173 subjects from Southern Turkey, comprising 96 patients with acute myocardial infarction (AMI) aged less than 55 years and 77 control subjects without cardiovascular disease.
I
Intervention
Presence of prothrombin 20210GA and factor V Leiden mutations
C
Comparator
Absence of mutations / control subjects without cardiovascular disease
O
Outcome
Development of acute myocardial infarctionhard clinical

Prothrombin 20210GA and factor V Leiden mutations are not significant risk factors for early-onset myocardial infarction in the Southern Turkish population.

Cite This Study

Dönmez et al. (2004) studied this question.

synapsesocial.com/papers/6a83dec707bf35307a997075https://doi.org/10.1536/jhj.45.505
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Common Prothrombin Variant (20210 G to A) Increases the Risk of Myocardial Infarction in Young Women1997 · 358 citations
  2. 2A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis1996 · 3,130 citations
  3. 3Myocardial Infarction With Angiographically Normal Coronary Arteries1994 · 90 citations
  4. 4Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)2001 · 26,202 citations
  5. 5Ethnic Distribution of Factor V Leiden in 4047 Men and Women1997 · 644 citations