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Reveals no significant link between MTHFR and MMP-9 gene variants and coronary artery disease, highlighting that these polymorphisms may not drive disease risk.
Objective: Coronary artery disease (CAD) is a multifactorial disease that influenced by both genetic and environmental factors. Single nucleotide polymorphisms (SNPs) in the candidate genes produce susceptibility to such multifactorial diseases. Therefore, investigations of SNPs, in the genes that may play role in etiopathogenesis of CAD, become crucial. In the present study we investigated the both independent and synergistically effects of matrix metalloproteinase (MMP) -1562 C/T and methylenetetrahydrofolate reductase (MTHFR) 677 C/T polymorphisms on the CAD occurrence.Methods: In total 217 individuals, 109 coronary artery disease patients and 108 healthy controls were examined. We determined the genotypes for MMP-9 -1562 C/T and MTHFR 677 C/T polymorphisms by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP).Results: We found no statistically significant differences between genotypes and allelic frequencies of both MMP-9 -1562 C/T and MTHFR 677 C/T polymorphisms and CAD (p>0.05). No TT homozygous genotype was found in any of groups for MMP9 -1562 C/T polymorphism. However, while C allele and CC genotype was found to be highly, TT genotype was found to be very rare for both polymorphisms in Southeastern Anatolia.Conclusion: We have found no associations between MMP9 -1562 C/T and MTHFR 677 C/T polymorphisms and coronary artery disease. However, TT genotype was determined to be very rare in Southeast Anatolia.
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Küçük et al. (2016) studied this question.
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