Key result
The MMP-9 gene rs3918242 CT+TT genotype was significantly associated with an increased risk of coronary artery disease compared to the CC genotype (OR 2.005) in the Chinese Han population.
Why the study?
Are MMP-9 gene polymorphisms (rs3918242 and rs17576) and serum MMP-9 levels associated with coronary artery disease in the Chinese Han population?
Population
411 subjects from the Chinese Han Population, comprising 258 cases with coronary artery disease and 153…
Comparison
Presence of MMP-9 gene polymorphisms and serum… vs Control group without CAD
Design
Case-control
Authors
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Should not yet change CAD risk assessment; leaves open MMP-9 rs3918242 utility pending prospective validation.
Case-Control (n=411)
No
Are MMP-9 gene polymorphisms (rs3918242 and rs17576) and serum MMP-9 levels associated with coronary artery disease in the Chinese Han population?
Odds Ratio: 2.005 (95% CI 1.178–3.414)
Absolute Event Rate: 25.2% vs 14.4%
p-value: p=0.009
The rs3918242 polymorphism in the MMP-9 gene and elevated serum MMP-9 levels are associated with coronary artery disease in the Chinese Han population.
Wu et al. (2013) conducted a case-control in Coronary Artery Disease (n=411). MMP-9 gene rs3918242 polymorphism (CT+TT genotype) vs. CC genotype was evaluated on Presence of coronary artery disease (OR 2.005, 95% CI 1.178-3.414, p=0.009). The MMP-9 gene rs3918242 CT+TT genotype was significantly associated with an increased risk of coronary artery disease compared to the CC genotype (OR 2.005) in the Chinese Han population.
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