Key result
The MMP-9-1562C>T gene polymorphism was significantly associated with an increased risk of coronary artery disease in the Chinese Han population (OR 1.60).
Why the study?
Is the MMP-9-1562C>T gene polymorphism associated with an increased risk of coronary artery disease in the Chinese Han population?
Meta-Analysis (n=5,468)
Is the MMP-9-1562C>T gene polymorphism associated with an increased risk of coronary artery disease in the Chinese Han population?
Odds Ratio: 1.6 (95% CI 1.25–2.04)
p-value: p=0.0002
The MMP-9-1562C>T gene polymorphism, specifically the -1562T allele, is significantly associated with an increased risk of coronary artery disease in the Chinese Han population.
May inform CAD risk models in Chinese Han; leaves open prospective validation before clinical use.
BACKGROUND: Multiple studies indicate that the matrix metalloproteinase-9 (MMP-9)-1562C>T gene polymorphism may be associated with an increased risk of coronary artery disease (CAD) in the Chinese Han population. However, a clear consensus has yet to be established. OBJECTIVE AND METHODS: A meta-analysis of 5468 subjects from 10 separate studies was performed to explore the possible relationship between the MMP-9-1562C>T gene polymorphism and CAD within the Chinese Han population. Pooled odds ratio (ORs) for the association and the corresponding 95% confidence intervals (CIs) were evaluated by a random or fixed-effect model. RESULTS: Our analysis confirms the association between the MMP-9-1562C>T gene polymorphism and an increased risk of CAD within the Chinese Han population under allelic (OR: 1.60, 95% CI: 1.25-2.04, P = 0.0002), recessive (OR: 3.05, 95% CI: 1.67-5.56, P = 0.0003), dominant (OR: 2.23, 95% CI: 1.49-3.35, P = 0.0001), homozygous (OR: 3.41, 95% CI: 1.87-6.23, P < 0.0001), heterozygous (OR: 2.03, 95% CI: 1.40-2.93, P = 0.0002), and additive genetic models (OR: 1.78, 95% CI: 1.33-2.39, P < 0.0001). CONCLUSIONS: In the Chinese Han population, the MMP-9-1562C>T gene polymorphism is correlated with an increased risk of CAD. Therefore, Han Chinese carriers of the -1562T allele may be at an increased risk of CAD.
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Li et al. (2016) conducted a meta-analysis in Coronary artery disease (n=5,468). MMP-9-1562C>T gene polymorphism vs. Wild-type genotype / non-carriers was evaluated on Risk of coronary artery disease (allelic model) (OR 1.60, 95% CI 1.25-2.04, p=0.0002). The MMP-9-1562C>T gene polymorphism was significantly associated with an increased risk of coronary artery disease in the Chinese Han population (OR 1.60).
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