Key result
eNOS D and TPO 5709G alleles linked to ~60% lower MI risk in young adults.
Why the study?
The role of genetic factors in the development of acute myocardial infarction in young adults remains undefined, particularly in genetically restricted populations.
Are hemostatic gene polymorphisms associated with the risk of acute myocardial infarction in young Sardinian adults?
Population
71 young Sardinian adults with first MI and 150 healthy subjects
Comparison
Patients with AMI vs healthy controls for hemostatic gene polymorphisms
Design
Case-control study
Authors
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TPO 5709G and eNOS4a alleles were associated with MI protection in young Sardinians; hypothesis-generating for haemostatic genetics in isolated populations.
Case-Control (n=221)
No
Are hemostatic gene polymorphisms associated with the risk of acute myocardial infarction in young Sardinian adults?
Odds Ratio: 0.4 (95% CI 0.19–0.82)
Absolute Event Rate: 7% vs 15.9%
p-value: p=0.016
The 5709G allele in the TPO gene and eNOS4a allele in the eNOS gene may confer protection against acute myocardial infarction in young Sardinian adults.
Ciriaco Carru (2010) conducted a case-control in Acute myocardial infarction (n=221). eNOS I/D and TPO A5709G gene polymorphisms vs. Healthy controls was evaluated on Risk of acute myocardial infarction associated with the eNOS D allele (OR 0.40, 95% CI 0.19-0.82, p=0.016). The eNOS D allele and TPO 5709G allele were associated with a significantly reduced risk of acute myocardial infarction in young Sardinian adults, with the eNOS D allele showing an OR of 0.40.
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