Why the study?
Do specific genetic polymorphisms increase the risk of myocardial infarction in patients under 45 years of age?
Do specific genetic polymorphisms increase the risk of myocardial infarction in patients under 45 years of age?
Specific genetic polymorphisms, including Leu125Val PECAM1 and A1/A2 FVII, are associated with premature myocardial infarction in patients under 45 years of age.
May support genetic risk assessment in young MI patients; leaves open prospective validation before clinical use.
This study investigates the potential role of 17 chosen polymorphisms in 15 candidate genes and the risk of myocardial infarction in patients under 45 years of age. The study consists of 271 patients with myocardial infarction and 141 controls. The analysis of genetic polymorphisms was performed using the PCR-RFLP method. Of the chosen polymorphisms, two (Leu125Val PECAM1 and A1/A2 FVII) are related to myocardial infarction and two (C677T MTHFR and 5A/6A MMP3) to advanced stenosis in arterial vessels (> 75%). We also found that the frequency of some combinations among the analyzed genes and environmental factors varied between the patient and control groups.
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Sakowicz et al. (2012) studied this question.
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