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December 11, 2002New England Journal of MedicineOpen Access

Prediction of the Risk of Myocardial Infarction from Polymorphisms in Candidate Genes

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Why the study?

Do specific genetic polymorphisms increase the risk of myocardial infarction in Japanese patients?

Population

5,061 unrelated Japanese subjects, including 2,819 patients with myocardial infarction and 2,242 controls.

Comparison

Presence of specific genetic polymorphisms. vs Absence of these polymorphisms / healthy controls.

Design

Case-control

Authors

YYYoshiji YamadaMie UniversityHIHideo IzawaGeneral CardiologySISahoko IchiharaGeneral / Preventive / Lipids

Discussion

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Implication

Should not change MI risk assessment or screening; leaves open need for prospective validation of these sex-specific associations.

Structured PICO

Do specific genetic polymorphisms increase the risk of myocardial infarction in Japanese patients?

P
Population
5,061 unrelated Japanese subjects, including 2,819 patients with myocardial infarction (2,003 men, 816 women) and 2,242 controls (1,306 men, 936 women).
I
Intervention
Presence of specific genetic polymorphisms (112 polymorphisms of 71 candidate genes).
C
Comparator
Absence of these polymorphisms / healthy controls.
O
Outcome
Risk of myocardial infarction.hard clinical

Polymorphisms in the connexin 37, plasminogen-activator inhibitor type 1, and stromelysin-1 genes are significantly associated with the risk of myocardial infarction in a sex-specific manner among Japanese patients.

Cite This Study

Yamada et al. (2002) studied this question.

synapsesocial.com/papers/6a85049b8beb37cebc84773dhttps://doi.org/10.1056/nejmoa021445
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Polymorphism of a Platelet Glycoprotein Receptor as an Inherited Risk Factor for Coronary Thrombosis1996 · 693 citations
  2. 2Carotid Intima-Media Thickness Is Associated With Allelic Variants of Stromelysin-1, Interleukin-6, and Hepatic Lipase Genes2002 · 205 citations
  3. 3Genetic--epidemiologic study of early-onset ischemic heart disease.1980 · 298 citations
  4. 4Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.1995 · 750 citations
  5. 5Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.1990 · 334 citations