What does this research mean for the field?

At least 34% of young patients (under 45 years) presenting with venous thrombosis in Western India have a demonstrable thrombophilic abnormality, though the prothrombin G20210A polymorphism appears to be nonexistent in this population. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 2001Clinical and Applied Thrombosis/Hemostasis

Venous Thromboembolism in Young Patients From Western India: A Study

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Population

432 young patients from Western India with venous thrombosis confirmed by ultrasound with Doppler or CT scan.

Design

Cohort

Authors

KGKanjaksha GhoshICMR - National Institute of Immunohaemotology SSShrimati ShettyK. J. Somaiya Hospital & Research Centre MMManisha MadkaikarICMR - National Institute of Immunohaemotology

Discussion

Member takes

Implication

May support targeted thrombophilia testing in young Western Indian thrombosis patients; extends regional prevalence data but leaves clinical utility open.

Structured PICO

Population

432 young patients (age 1-45 years, 252 males and 180 females) from Western India with venous thrombosis confirmed by ultrasound with Doppler or CT scan.

Outcome

Prevalence of thrombophilia markers (protein C, protein S, antithrombin III, factor V Leiden, prothrombin G20210A, MTHFR C677T, lupus inhibitor, anticardiolipin antibodies)surrogate

In young patients from Western India with venous thrombosis, at least 34% have a demonstrable thrombophilia marker, with protein C deficiency and MTHFR C677T polymorphism being relatively common, while the prothrombin G20210A polymorphism appears nonexistent.

Cite This Study

Ghosh et al. (2001) studied this question.

synapsesocial.com/papers/6a1eb52e6b4935698da43967 https://doi.org/10.1177/107602960100700214

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Implication

May support targeted thrombophilia testing in young Western Indian thrombosis patients; extends regional prevalence data but leaves clinical utility open.