Why the study?
What is the absolute risk of venous thrombosis associated with various known thrombophilic defects in relatives of patients with thrombosis?
Population
2479 relatives of probands who had thrombosis and a thrombophilic defect
Design
Cohort
Authors
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May guide selective testing toward antithrombin, protein C, and protein S deficiencies; extends absolute risk data in relatives.
What is the absolute risk of venous thrombosis associated with various known thrombophilic defects in relatives of patients with thrombosis?
Thrombophilia testing should focus on hereditary deficiencies of antithrombin, protein C, and protein S in patients with a first venous thrombosis at a young age or with a strong family history, due to their significantly higher absolute thrombotic risk.
Lijfering et al. (2009) studied this question.
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