Key result
Factor V Leiden presents milder manifestations but no significantly lower thrombosis risk versus other deficiencies.
Why the study?
No direct comparison of thrombotic risk associated with antithrombin, protein C, protein S deficiencies, and factor V Leiden mutation was available.
Does the specific type of inherited thrombophilia affect the lifetime risk and severity of thrombosis in relatives of affected patients?
Observational (n=723)
Does the specific type of inherited thrombophilia affect the lifetime risk and severity of thrombosis in relatives of affected patients?
Relative Risk: 0.3 (95% CI 0.1–1.6)
Factor V Leiden is associated with a significantly lower risk and less severe manifestations of venous thrombosis compared to deficiencies in antithrombin, protein C, or protein S.
No takes yet. Share an insight, caveat, or question.
Supports subtype-specific risk estimates in relatives; hypothesis-generating and requires prospective validation before guiding management.
Martinelli et al. (1998) conducted an observational in Inherited thrombophilia (n=723). Factor V Leiden vs. Antithrombin, protein C, or protein S deficiency was evaluated on Lifetime probability of developing thrombosis (RR 0.3, 95% CI 0.1-1.6). Factor V Leiden is associated with a lower risk of thrombosis compared to antithrombin, protein C, or protein S deficiency (RR 0.3; 95% CI 0.1-1.6), and presents with less severe manifestations.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: