Key result
Combined protein C/S and factor V Leiden defects linked to thrombosis ~14 years earlier vs single defects.
Why the study?
Does a combined genetic defect (protein C or S deficiency plus factor V Leiden) increase the risk and lower the age of onset of thrombosis compared to a single defect?
Observational (n=58)
Does a combined genetic defect (protein C or S deficiency plus factor V Leiden) increase the risk and lower the age of onset of thrombosis compared to a single defect?
Absolute Event Rate: 18.4% vs 32.6%
p-value: p=< 0.001
Individuals with a combined genetic defect of protein C or S deficiency and factor V Leiden have a significantly higher risk and earlier onset of thrombosis compared to those with a single defect.
No takes yet. Share an insight, caveat, or question.
May warrant earlier family screening; extends single-defect observations but remains hypothesis-generating.
Mustafa et al. (1998) conducted an observational in Thrombophilia (n=58). Combined genetic defect (protein C or S deficiency and factor V Leiden) vs. Single genetic defect (protein C or S deficiency alone) was evaluated on Age at first thrombosis (p=< 0.001). A combined genetic defect of protein C or S deficiency with factor V Leiden significantly lowered the mean age at first thrombosis compared to a single defect (18.4 vs 32.6 years; P<0.001).
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