Key result
Inherited thrombophilia linked to ~660% higher symptomatic VTE risk in relatives of pediatric VTE patients.
Why the study?
Does the presence of inherited thrombophilia increase the risk of symptomatic VTE in relatives of pediatric VTE patients?
Population
533 first- and second-degree relatives of 206 pediatric patients with venous thromboembolism (VTE)
Comparison
Presence of inherited thrombophilia vs Absence of inherited thrombophilia
Design
Cohort
Authors
Loading...
May support targeted screening in relatives of pediatric VTE patients; leaves open whether testing improves outcomes.
Observational (n=533)
Does the presence of inherited thrombophilia increase the risk of symptomatic VTE in relatives of pediatric VTE patients?
Hazard Ratio: 7.6 (95% CI 4–14.5)
p-value: p=< .001
Relatives of pediatric VTE patients who carry inherited thrombophilias, particularly antithrombin, protein C, or protein S deficiency, have a substantially increased risk of symptomatic VTE, supporting targeted screening in this population.
Holzhauer et al. (2012) conducted an observational in Venous thromboembolism (VTE) (n=533). Inherited thrombophilia vs. No inherited thrombophilia was evaluated on Symptomatic VTE (HR 7.6, 95% CI 4.0-14.5, p=< .001). Inherited thrombophilia significantly increased the risk of symptomatic VTE among relatives of pediatric VTE patients compared to those without thrombophilia (HR 7.6; 95% CI 4.0-14.5; P<.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: