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June 1, 2007Angiology

Plasma Levels of B-Type Natriuretic Peptide in Patients With Unstable Angina Pectoris or Acute Myocardial Infarction: Prognostic Significance and Therapeutic Implications

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Why the study?

Does elevated plasma BNP predict adverse outcomes and identify patients who benefit from early revascularization in unstable angina or acute MI?

Population

146 patients with unstable angina pectoris, non-ST-segment elevation myocardial infarction, or ST-segment…

Comparison

Elevated plasma B-type natriuretic peptide… vs Normal plasma BNP level (<=80 pg/mL)

Design

Cohort

Follow-up

1 month

Authors

WAWaqas AhmedSZSaman ZafarAAAli Yawar Alam

Discussion

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Member takes

Overview

Elevated BNP may flag higher-risk ACS patients; leaves open whether early revascularization improves outcomes in this subgroup.

Structured PICO

Does elevated plasma BNP predict adverse outcomes and identify patients who benefit from early revascularization in unstable angina or acute MI?

P
Population
146 patients with unstable angina pectoris, non-ST-segment elevation myocardial infarction (MI), or ST-segment elevation MI
I
Intervention
Elevated plasma B-type natriuretic peptide (BNP) levels (>80 pg/mL) and early revascularization (percutaneous intervention or coronary artery bypass grafting)
C
Comparator
Normal plasma BNP level (<=80 pg/mL)
O
Outcome
Presence of new heart failure, recurrent MI or ischemia, or death 1 month after the index eventhard clinical

Elevated BNP (>80 pg/mL) in acute coronary syndromes predicts higher risk of heart failure and mortality, identifying a high-risk subgroup that specifically benefits from early revascularization.

Cite This Study

Ahmed et al. (2007) studied this question.

synapsesocial.com/papers/6a7fd9b6cab4e68c85153169https://doi.org/10.1177/0003319707302543
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma Brain Natriuretic Peptide as an Indicator of Left Ventricular Systolic Function and Long-term Survival After Acute Myocardial Infarction1996 · 702 citations
  2. 2Rapid Measurement of B-Type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure2002 · 3,383 citations
  3. 3Guidelines for Percutaneous Coronary Interventions2005 · 1,615 citations
  4. 4The Natural History of Congestive Heart Failure: The Framingham Study1971 · 3,492 citations
  5. 5B-type natriuretic peptide at presentation and prognosis in patients with ST-segment elevation myocardial infarction2004 · 210 citations