The asymmetric Robinson cyclization reaction was studied by using polymer‐bound L ‐prolines as catalysts, in which the degree of crosslinking, the content of proline and the spacers of binding L ‐proline to the polymers were varied. Incorporation of a spacer for binding the L ‐proline moiety onto a polymer support was found to improve the catalytic efficiency considerably, which is reflected by the value of enantiomeric excess.
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Kondo et al. (1985) studied this question.
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