Why the study?
Does aging reduce maximal O2 uptake in rat skeletal muscles when convective O2 delivery is matched?
Population
Young adult (8 months) and late middle-aged (28-30 months) Fischer 344 x Brown Norway F1 hybrid rats
Comparison
In situ pump-perfused hindlimb preparation with… vs Young adult rats compared to late middle-aged rats
Design
Preclinical
Authors
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Intrinsic muscle changes may limit VO2 max with aging independent of delivery; hypothesis-generating for human sarcopenia and exercise intolerance.
Does aging reduce maximal O2 uptake in rat skeletal muscles when convective O2 delivery is matched?
Alterations within skeletal muscles, such as reduced mitochondrial oxidative capacity, contribute to the age-related decline in maximal O2 uptake independent of convective O2 delivery.
Hepple et al. (2003) studied this question.
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