Why the study?
Does gene expression differ between intra-abdominal and subcutaneous fat in morbidly obese versus nonobese men?
Does gene expression differ between intra-abdominal and subcutaneous fat in morbidly obese versus nonobese men?
Intra-abdominal fat extent correlates with metabolic coronary risk factors, and planned gene expression studies may further elucidate its role as a common denominator in metabolic syndrome.
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Intra-abdominal fat extent was associated with metabolic risk factors; leaves open gene expression differences by depot in morbid obesity.
Extent of intra-abdominal fat had significant linear relations with six metabolic coronary risk factors: systolic and diastolic blood pressure, fasting blood concentrations of glucose, high density lipoprotein (HDL) cholesterol, triglyceride, and plasminogen activator inhibitor-1. Tumor necrosis factor-alpha and adiponectin can be biological mediators from the intra-abdominal fat to the metabolic coronary risk factors. Complementarily, we describe a new study that will analyze the gene expression in intra-abdominal and subcutaneous fat on mRNA and protein level using high throughput methods. The study will elucidate further whether intra-abdominal obesity is the common denominator for the different components of the metabolic syndrome.
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Eyben et al. (2004) studied this question.
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