Key result
Omental adipose tissue from obese men showed 89 up-regulated and 64 down-regulated genes compared to lean men, including blunted lipolysis inducers and down-regulated growth factors.
Why the study?
What are the differences in gene expression profiles of omental adipose tissue between obese and lean individuals?
Observational (n=6)
What are the differences in gene expression profiles of omental adipose tissue between obese and lean individuals?
Obesity is associated with significant alterations in omental adipose tissue gene expression, including down-regulation of lipolysis and growth factor genes and up-regulation of MAPKs.
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Suggests potential mechanisms of obesity-related metabolic dysfunction; leaves open whether modulating these genes improves outcomes.
Gómez‐Ambrosi et al. (2003) conducted an observational in Obesity (n=6). Obesity vs. Lean volunteers was evaluated on Gene expression pattern of omental adipose tissue. Omental adipose tissue from obese men showed 89 up-regulated and 64 down-regulated genes compared to lean men, including blunted lipolysis inducers and down-regulated growth factors.
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