Key result
MicroRNA expression in human adipose tissue is fat-depot specific, with 16 miRNAs showing significant expression differences between omental and subcutaneous depots, and correlates with adipocyte phenotype and metabolic parameters.
Population
15 overweight and obese individuals, including those with normal glucose tolerance and newly diagnosed type…
Design
Cross-sectional
Authors
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May guide mechanistic studies in obesity; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=15)
No
miRNA expression differs between omental and subcutaneous fat depots and correlates with key metabolic parameters in obesity and type 2 diabetes.
Klöting et al. (2009) conducted a cross-sectional in Obesity and Type 2 Diabetes (n=15). Omental adipose tissue and Type 2 Diabetes status vs. Subcutaneous adipose tissue and normal glucose tolerance was evaluated on MicroRNA expression differences between omental and subcutaneous adipose tissue, and between NGT and T2D patients. MicroRNA expression in human adipose tissue is fat-depot specific, with 16 miRNAs showing significant expression differences between omental and subcutaneous depots, and correlates with adipocyte phenotype and metabolic parameters.
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