May 1, 2008AJP Regulatory Integrative and Comparative Physiology

Inflammation is associated with a decrease of lipogenic factors in omental fat in women

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Population

24 women: 6 lean normoglycemic and 18 obese volunteers with different glycemic states

Design

Cross-sectional

Authors

OPOdile Poulain‐GodefroyCentre National de la Recherche Scientifique FPFrançois PattouCentre National de la Recherche Scientifique GFGema FrühbeckMRC Human Nutrition Research

Discussion

Member takes

Implication

Omental inflammation may impair lipogenic pathways in visceral fat; hypothesis-generating for diabetes mechanisms and requires prospective confirmation.

Structured PICO

Population

24 women: 6 lean normoglycemic and 18 obese volunteers with different glycemic states (normoglycemic, glucose-intolerant, or type 2 diabetic)

Outcome

Expression levels of CD14, IL-18, leptin, adiponectin, SREBP1, PPARgamma, PBEF1, GPD1, LPL, FABP4, and HIF1alpha in paired omental and subcutaneous adipose tissue biopsiessurrogate

In human omental adipose tissue, increased inflammation is associated with decreased expression of lipogenic markers, particularly in diabetic subjects.

Cite This Study

Poulain‐Godefroy et al. (2008) studied this question.

synapsesocial.com/papers/6a7de97c14e877b18fa14b1d https://doi.org/10.1152/ajpregu.00926.2007

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Implication

Omental inflammation may impair lipogenic pathways in visceral fat; hypothesis-generating for diabetes mechanisms and requires prospective confirmation.