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June 16, 2017The Journal of Clinical Endocrinology & MetabolismOpen Access

Expression of CEBPA, ADIPOQ, IRS1, IRS2, SLC2A4, and MMP9 in adipose tissue was associated with insulin sensitivity independently of body mass index.

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Population

150 young, healthy subjects (83 normal-weight, 48 overweight, and 19 obese)

Design

Cross-sectional

Authors

NMNatalia MatulewiczMSMagdalena StefanowiczANAgnieszka Nikołajuk

Discussion

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Overview

Suggests adipogenesis and extracellular matrix remodeling may drive metabolic risk before clinical disease; leaves open whether targeting.

Structured PICO

P
Population
150 young, healthy subjects (83 normal-weight, 48 overweight, and 19 obese)
C
Comparator
Normal-weight subjects
O
Outcome
Subcutaneous adipose tissue gene expression of markers of adipogenesis, extracellular matrix remodeling, and inflammation, and their association with insulin sensitivitysurrogate

In young, healthy individuals, overweight and obesity are associated with altered adipose tissue gene expression, with adipogenesis and extracellular matrix remodeling being independently associated with insulin sensitivity.

Cite This Study

Matulewicz et al. (2017) studied this question.

synapsesocial.com/papers/6a83b6fc42ccde92f8c5767bhttps://doi.org/10.1210/jc.2017-00597
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