Key result
Adipose tissue inflammation markers were not significantly associated with adipose tissue insulin resistance after adjustment for fat cell size, which was a strong predictor of insulin resistance.
Why the study?
The role of adipose tissue inflammation in adipose tissue function in humans is unclear.
Is adipose tissue inflammation related to adipose insulin resistance in humans?
Population
86 volunteers with normal weight or obesity, including a subgroup of 25 volunteers with obesity
Comparison
Subgroup of 25 volunteers before vs after 10% weight loss
Authors
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Fat cell size, not inflammation markers, predicts adipose insulin resistance; leaves open causal mechanisms and therapeutic targets.
Observational (n=86)
Is adipose tissue inflammation related to adipose insulin resistance in humans?
Fat cell size, rather than commonly used markers of adipose tissue inflammation, is a strong predictor of adipose tissue insulin resistance.
Ycaza et al. (2021) conducted an observational in Normal weight or obesity (n=86). Adipose tissue inflammation markers was evaluated on Adipose tissue insulin resistance (IC50). Adipose tissue inflammation markers were not significantly associated with adipose tissue insulin resistance after adjustment for fat cell size, which was a strong predictor of insulin resistance.
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