January 1, 1989Thrombosis and Haemostasis

Platelet Size Affects both Micro- and Macro-Aggregation: Contributions of Platelet Number, Volume Fraction and Cell Surface

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Population

Human platelet subpopulations separated on the basis of volume using counterflow centrifugation

Comparison

Large platelets stimulated with ADP, U46619, and… vs Small platelets (v = 4.2 +/- 0.2 fl)

Design

Preclinical

Authors

TWTruman WongMcGill University LPL G PedvisMcGill University MFMony M. FrojmovicInserm

Discussion

Member takes

Implication

Larger platelet ADP responsiveness in animal models is hypothesis-generating; leaves open translation to human thrombosis risk or antiplatelet strategies.

Structured PICO

Population

Human platelet subpopulations separated on the basis of volume using counterflow centrifugation

Intervention

Large platelets (v = 7.3 +/- 0.2 fl) stimulated with ADP, U46619, and PAF

Comparator

Small platelets (v = 4.2 +/- 0.2 fl)

Outcome

Micro-aggregation (PA) and macro-aggregation (TA)surrogate

Larger platelet size optimizes both micro- and macro-aggregation due to geometric advantages and intrinsic membrane surface differences.

Cite This Study

Wong et al. (1989) studied this question.

synapsesocial.com/papers/6a7fe566ab6b2b0dd579a24f https://doi.org/10.1055/s-0038-1646893

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Implication

Larger platelet ADP responsiveness in animal models is hypothesis-generating; leaves open translation to human thrombosis risk or antiplatelet strategies.

Platelet Size Affects both Micro- and Macro-Aggregation: Contributions of Platelet Number, Volume Fraction and Cell Surface

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Platelet Size Affects both Micro- and Macro-Aggregation: Contributions of Platelet Number, Volume Fraction and Cell Surface

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider