Key result
Platelet size and age independently determine platelet function, with larger platelets aggregating more rapidly than smaller ones, and younger platelets being more active than older ones.
Population
Baboon megakaryocytes/platelets labeled in vivo with 75Se-methionine
Comparison
Separation into size-dependent subpopulations… vs Comparison between different platelet sizes and…
Design
Preclinical
Authors
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May refine platelet function test interpretation; leaves open effects on clinical outcomes or therapy selection.
This preclinical study demonstrates that platelet size and age independently determine platelet function, with larger and younger platelets being more active.
Cb et al. (1984) studied this question. Platelet size and age was evaluated on In vitro platelet function (thrombin-induced aggregation). Platelet size and age independently determine platelet function, with larger platelets aggregating more rapidly than smaller ones, and younger platelets being more active than older ones.
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