Key result
Aging is associated with a stable platelet count that falls in old age and an increase in platelet function during middle age, driven by changes in hematopoietic tissue and oxidative stress.
This review highlights the critical gap in understanding platelet function in the elderly (>75 years), emphasizing that age-related changes in platelet biology must be addressed to develop more precise anti-platelet therapies for older patients.
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Challenges longstanding view of rising platelet reactivity with age; leaves open whether age should inform antiplatelet strategies in trials.
Chris I. Jones (2016) conducted a review in Aging and platelet function. Aging vs. Younger age was evaluated. Aging is associated with a stable platelet count that falls in old age and an increase in platelet function during middle age, driven by changes in hematopoietic tissue and oxidative stress.
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