Key result
Increased proportions of newly formed platelets are associated with an increased risk of thrombotic events and a reduced effectiveness of standard anti-platelet therapies.
Why the study?
Common intrinsic changes occurring as platelets age in the circulation are only just being explored, and understanding natural platelet ageing may identify triggers for altered platelet life span and reactivity.
Design
Review
Authors
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Hypothesis-generating for reticulated platelet monitoring; prospective trials needed before clinical adoption.
This review highlights the role of platelet ageing and newly formed platelets in thrombotic risk and anti-platelet therapy effectiveness.
Allan et al. (2022) conducted a review in Platelet ageing. Platelet ageing was evaluated. Increased proportions of newly formed platelets are associated with an increased risk of thrombotic events and a reduced effectiveness of standard anti-platelet therapies.
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