Key result
Aging is associated with increased platelet hyperactivity, decreased platelet count, and altered biochemical pathways, which may contribute to the higher incidence of cardiovascular and thrombotic diseases in the elderly.
Why the study?
Although platelet aggregability increases in vascular diseases, the contribution of age-related changes in platelet biology to cardiovascular risk is not well-understood.
Answers are grounded in this paper and cite their sources.
Age-related biochemical and structural changes in platelets lead to hyperactivity, which may contribute to the increased incidence of cardiovascular and thrombotic diseases in the elderly.
Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that platelet aggregability is increased in vascular diseases, the contribution of age-related changes in platelet biology to cardiovascular risk is not well-understood. Several lines of evidence support that platelets from older subjects differ in their function and structure, making platelets more prone to activation and less sensitive to inhibition. These age-related changes could lead to platelet hyperactivity and to the development of a prothrombotic state in advanced age. This review will focus on platelet biochemical modifications during aging and on the mechanisms by which these alterations could lead to thrombotic disease.
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Blanc et al. (2019) conducted a review in Aging and cardiovascular disease/thrombosis. Aging vs. Younger age was evaluated. Aging is associated with increased platelet hyperactivity, decreased platelet count, and altered biochemical pathways, which may contribute to the higher incidence of cardiovascular and thrombotic diseases in the elderly.
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