Key result
Aging alters platelet functions, promoting a prothrombotic and proinflammatory milieu that contributes to the risk of adverse clinical events in older adults.
This review highlights how aging-related alterations in platelet function contribute to thromboinflammatory diseases and discusses the implications for antiplatelet therapies in older adults.
Alerts clinicians to platelet-driven thrombotic risk in older adults; leaves open whether targeting these changes improves outcomes.
Platelets have a dynamic functional repertoire that mediates hemostatic and inflammatory responses. Many of these functions are altered in older adults, promoting a prothrombotic, proinflammatory milieu and contributing to risk of adverse clinical events. Drawing primarily from human studies, this review summarizes important aspects of aging-related changes in platelets. The relationship between altered platelet functions and thrombotic and inflammatory disorders in older adults is highlighted. Established and developing antiplatelet therapies for the treatment of thrombotic and inflammatory disorders are also discussed in light of these data.
No takes yet. Share an insight, caveat, or question.
Mohebali et al. (2014) conducted a review in Thromboinflammatory Disease. Aging was evaluated. Aging alters platelet functions, promoting a prothrombotic and proinflammatory milieu that contributes to the risk of adverse clinical events in older adults.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: