Population
732 patients treated with dabigatran, rivaroxaban, or apixaban hospitalized for severe bleeding
Design
Cohort
Follow-up
30 days
Authors
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Highlights the substantial risk of severe DOAC-related bleeding despite available reversal agents; leaves open the optimal.
In patients hospitalized for severe bleeding while on direct oral anticoagulants, 30-day mortality was 14%, and management strategies such as the use of prothrombin complex concentrates varied widely.
Albaladejo et al. (2017) studied this question.
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