Why the study?
Does prothrombin complex concentrate improve hemostasis and reduce plasma transfusion in patients with perioperative coagulopathy or bleeding?
Population
Patients with severe perioperative bleeding, trauma, or requiring acute reversal of warfarin or novel oral…
Comparison
Prothrombin complex concentrate, including… vs Plasma transfusion or conventional coagulation…
Design
Review
Authors
Loading...
May support viscoelastic-guided PCC use to minimize plasma in perioperative coagulopathy; prospective RCTs needed before routine adoption.
Does prothrombin complex concentrate improve hemostasis and reduce plasma transfusion in patients with perioperative coagulopathy or bleeding?
PCCs offer a rapid, low-volume alternative to plasma for warfarin reversal and, when guided by viscoelastic testing, can reduce plasma requirements in complex perioperative bleeding.
Tanaka et al. (2014) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: