Primary malignant epithelioid hemangioendothelioma of the pleura: A review and report of a novel case

FIGURE 1. Chest computerized tomography in favor of left‐sided pleural effusion and mass (demonstrated with yellow arrow)

FIGURE 2. Pathological evaluation of primary malignant epithelioid hemangioendothelioma of the pleura; (A) section of tumor which shows a spindle cell proliferation without nuclear atypia (H&E, ×200); (B) spindle cell proliferation with hemangiopericytoma like vessels (H&E, ×100); (C) Ki67 staining which shows a low proliferative index; (D) positive CD34 immunostaining

FIGURE 3. A hypermetabolic nodule in the right lower lobe, adjacent to oblique right fissure with SUV of 4.39 at maximum and hypermetabolic primary tumoral involvement in the right parietal and mediastinal pleura, along with malignant right effusion were noted. Diffuse irregular pleural thickening is noted on the right side, showing increased FDG activity (SUVmax: up to 7.98)

FIGURE 4. Frequency of primary pleural malignant epithelioid hemangioendothelioma from 1943 to 2019 based on published research