Why the study?
Heart substructures are not uniformly radiosensitive and radiation dose to the heart base drives radiation cardiotoxicity, prompting characterization of late regional gene expression changes using spatial transcriptomics.
Does base-targeted irradiation induce spatial gene expression changes and reduce ejection fraction in aged female C57BL/6 mice?
Population
Two aged female C57BL/6 mice
Comparison
16 Gy irradiation to the cranial third of the heart vs sham irradiation
Design
Preclinical animal study
Follow-up
30 weeks
Authors
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Base irradiation may impair murine cardiac function; leaves open whether regional transcriptomics can guide heart-sparing radiotherapy in patients.
Does base-targeted irradiation induce spatial gene expression changes and reduce ejection fraction in aged female C57BL/6 mice?
Spatial transcriptomics reveals that base-targeted cardiac irradiation in mice causes significant regional gene expression changes and reduces ejection fraction, providing insights into radiation cardiotoxicity.
Walls et al. (2022) studied this question.
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