What question did this study set out to answer?

To assess whether combining chlorfenapyr indoor residual spraying with pyrethroid long-lasting insecticidal nets improves vector control and counters pyrethroid resistance in malaria vectors.

November 16, 2011Malaria JournalOpen Access

Combining indoor residual spraying with chlorfenapyr and long-lasting insecticidal bed nets for improved control of pyrethroid-resistant Anopheles gambiae: an experimental hut trial in Benin

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To assess whether combining chlorfenapyr indoor residual spraying with pyrethroid long-lasting insecticidal nets improves vector control and counters pyrethroid resistance in malaria vectors.
Conducted an experimental hut trial in southern Benin evaluating chlorfenapyr indoor residual spraying (IRS), WHO-approved pyrethroid long-lasting insecticidal nets (LLINs) with 6 or 80 holes, and their combination against pyrethroid-resistant Anopheles gambiae and Culex quinquefasciatus.
Measured mosquito mortality, blood-feeding inhibition, and deterrence, alongside genotyping An. gambiae for the kdr pyrethroid resistance mutation.
Vector mortality in An. gambiae (84% kdr frequency) reached 82% to 83% with the combination treatments, significantly higher than with chlorfenapyr IRS alone (57%) or LLINs alone (37% for 6-hole, 49% for 80-hole nets).
Blood-feeding rates were inhibited primarily by LLINs (12% for 6-hole nets, 32% for 80-hole nets vs. 54–56% for untreated nets), with the combination yielding rates that did not differ from LLIN monotherapy.
Mortality among Culex quinquefasciatus was significantly greater in the combination arms (41% and 51%) compared to chlorfenapyr IRS alone (32%) or LLIN alone (13% and 15%).

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Implication

Experimental hut trial demonstrates improved vector mortality and personal protection in pyrethroid-resistant mosquitoes, suggesting an effective dual-intervention strategy.

Cite This Study

Ngufor et al. (2011) studied this question.

synapsesocial.com/papers/6a7fea768ec27438f6a2879e https://doi.org/10.1186/1475-2875-10-343

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Implication

Experimental hut trial demonstrates improved vector mortality and personal protection in pyrethroid-resistant mosquitoes, suggesting an effective dual-intervention strategy.

Combining indoor residual spraying with chlorfenapyr and long-lasting insecticidal bed nets for improved control of pyrethroid-resistant Anopheles gambiae: an experimental hut trial in Benin

Key Points

Discussion

Implication

Cite This Study

Combining indoor residual spraying with chlorfenapyr and long-lasting insecticidal bed nets for improved control of pyrethroid-resistant Anopheles gambiae: an experimental hut trial in Benin

Key Points

Discussion

Implication

Cite This Study

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