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April 1, 1993NeurologyOpen Access

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

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Why the study?

Does interferon beta-1b reduce MRI-detected disease activity in patients with relapsing-remitting multiple sclerosis?

Population

372 patients with relapsing-remitting multiple sclerosis

Comparison

Interferon beta-1b vs Placebo

Design

RCT, randomized, double-blind

Authors

DPD. W. PatyWestern UniversityDLD.K.B. Li

Discussion

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Implication

Supports interferon beta-1b in RRMS; confirms MRI endpoints as responsive and strengthens disease-modifying role.

Structured PICO

Does interferon beta-1b reduce MRI-detected disease activity in patients with relapsing-remitting multiple sclerosis?

P
Population
372 patients with relapsing-remitting multiple sclerosis (327 included in yearly MRI analysis, 52 in frequent MRI cohort)
I
Intervention
Interferon beta-1b
C
Comparator
Placebo
O
Outcome
Disease activity measured by numbers of active scans and appearance of new lesions on MRI, and MRI-detected burden of diseasesurrogate

Interferon beta-1b significantly reduces MRI-detected disease activity and burden of disease in patients with relapsing-remitting multiple sclerosis.

Cite This Study

Paty et al. (1993) studied this question.

synapsesocial.com/papers/6a7feabf5057f76705c854e3https://doi.org/10.1212/wnl.43.4.662
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines.1991 · 371 citations
  2. 2Systemic lymphoblastoid interferon therapy in chronic progressive multiple Sclerosis. I. Clinical and MRI evaluation1990 · 78 citations
  3. 3Serial study of gadolinium‐DTPA MRI enhancement in multiple sclerosis1990 · 113 citations
  4. 4SERIAL GADOLINIUM ENHANCED MAGNETIC RESONANCE IMAGING IN MULTIPLE SCLEROSIS1988 · 408 citations
  5. 5Interrater variability with the Expanded Disability Status Scale (EDSS) and Functional Systems (FS) in a multiple sclerosis clinical trial1990 · 330 citations