November 1, 1978Annals of Internal Medicine

The Myocarditis of Systemic Lupus Erythematosus

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Population

140 consecutive patients with systemic lupus erythematosus, along with a detailed analysis of 5 patients…

Design

Cohort

Authors

DBDavid BorensteinArthritis and Rheumatism Associates

Discussion

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Implication

May prompt cardiac evaluation in SLE myositis; hypothesis-generating for shared mechanisms, needs prospective validation.

Structured PICO

Population

140 consecutive patients with systemic lupus erythematosus (retrospective review), along with a detailed analysis of 5 patients with clinically overt myocarditis in the setting of SLE (3 of whom were in the 140-patient cohort).

Outcome

Association of myocarditis with clinical and serologic features, specifically myositis and antibodies to nuclear ribonucleoprotein (RNP).

Myocarditis in systemic lupus erythematosus is strongly associated with myositis, suggesting a generalized inflammatory process directed against striated muscle.

Limitations

Small sample size for the anti-RNP antibody analysis

Cite This Study

David Borenstein (1978) studied this question.

synapsesocial.com/papers/6a7feae933a54265d53d2dca https://doi.org/10.7326/0003-4819-89-5-619

Topics

Myocarditis

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The Myocarditis of Systemic Lupus Erythematosus

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

The Myocarditis of Systemic Lupus Erythematosus

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

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