What question did this study set out to answer?

To summarize current hypotheses on the pathogenesis of rheumatic fever and autoimmune sequelae affecting the heart valve and brain following group A streptococcal infections.

May 30, 2012Current Opinion in RheumatologyOpen Access

Streptococcus and rheumatic fever

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MCMadeleine W. CunninghamGeneral Cardiology

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Implication

Narrative review reveals molecular mimicry mechanisms driving cardiac and neuronal damage in group A streptococcal infections, highlighting cross-reactive autoantibodies in disease pathogenesis.

Key Points

To summarize current hypotheses on the pathogenesis of rheumatic fever and autoimmune sequelae affecting the heart valve and brain following group A streptococcal infections.
Synthesized molecular and immunological findings from human monoclonal antibodies derived from rheumatic heart disease and Sydenham chorea.
Evaluated cellular and humoral cross-reactivity between streptococcal antigens (M protein, GlcNAc) and host tissues (cardiac myosin, laminin, neuronal gangliosides, dopamine receptors).
Human monoclonal antibodies cross-react with streptococcal carbohydrate epitope GlcNAc and host extracellular targets, including heart valve laminin and neuronal dopamine receptors.
A proposed two-hit mechanism initiates rheumatic heart disease through antibody-mediated valve endothelial activation followed by cross-reactive T-cell extravasation and Aschoff body formation.
In Sydenham chorea, cross-reactive autoantibodies stimulate neuronal cells by activating calcium calmodulin-dependent protein kinase II (CaMKII) and binding extracellular surface gangliosides and dopamine receptors.

Cite This Study

Madeleine W. Cunningham (2012) studied this question.

synapsesocial.com/papers/6a7febf81024bacc969276d2 https://doi.org/10.1097/bor.0b013e32835461d3

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Implication

Narrative review reveals molecular mimicry mechanisms driving cardiac and neuronal damage in group A streptococcal infections, highlighting cross-reactive autoantibodies in disease pathogenesis.

Streptococcus and rheumatic fever

Discussion

Member takes

Implication

Key Points

Cite This Study

Streptococcus and rheumatic fever

Discussion

Member takes

Implication

Key Points

Cite This Study

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