July 25, 2006Journal of Pineal Research

Melatonin reduces ischemia/reperfusion‐induced superoxide generation in arterial wall and cell death in skeletal muscle

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Why the study?

Does melatonin reduce ischemia/reperfusion-induced superoxide generation and cell death in a preclinical model?

Structured PICO

Does melatonin reduce ischemia/reperfusion-induced superoxide generation and cell death in a preclinical model?

Population

Preclinical model of prolonged ischemia (4 hr) in cremaster muscle and feeding vessels (iliac, femoral, and spermatic arteries)

Intervention

Melatonin via intravenous injection 10 min prior to and 10 min after reperfusion

Comparator

Vehicle via intravenous injection; internal control of unclamped contralateral arteries

Outcome

Superoxide generation in arterial wall (early phase) and endothelial dysfunction/cell viability in cremaster muscle (24 hr)surrogate

Melatonin attenuates ischemia/reperfusion injury by reducing early superoxide generation, thereby preserving endothelial function and muscle cell viability.

Discussion

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Implication

Hypothesis-generating for melatonin in ischemia-reperfusion injury; clinical trials required before any practice consideration.

Cite This Study

Wang et al. (2006) studied this question.

synapsesocial.com/papers/6a7fed2c527a4b4caa31adf2 https://doi.org/10.1111/j.1600-079x.2006.00361.x

View Full Paper

Ask AI

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Melatonin reduces ischemia/reperfusion‐induced superoxide generation in arterial wall and cell death in skeletal muscle

Structured PICO

Discussion

Implication

Cite This Study

Melatonin reduces ischemia/reperfusion‐induced superoxide generation in arterial wall and cell death in skeletal muscle

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider