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Reveals an association between late-pregnancy SSRI exposure and persistent pulmonary hypertension in newborns, highlighting uncertainty regarding underlying maternal illness confounding.
Use of selective serotonin reuptake inhibitors (SSRIs) in late pregnancy has been associated with persistent pulmonary hypertension of the newborn (PPHN), a rare condition with substantial infant mortality and morbidity. Although the increase in absolute risk is small on a population level, it may be of concern to many patients. It remains unclear the extent to which the increased risks reported for PPHN are explained by the underlying maternal illness rather than the use of SSRIs.
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Alwan et al. (2016) studied this question.
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