Why the study?
To investigate the levels of apelin-36, glucose metabolism parameters, and cardiovascular risk factors across patients with impaired fasting glucose, combined impaired fasting glucose and tolerance, newly diagnosed type 2 diabetes mellitus, and controls.
Do serum apelin-36 levels differ among patients with impaired fasting glucose, impaired glucose tolerance, newly diagnosed type 2 diabetes mellitus, and healthy controls?
Do serum apelin-36 levels differ among patients with impaired fasting glucose, impaired glucose tolerance, newly diagnosed type 2 diabetes mellitus, and healthy controls?
Serum apelin-36 levels are significantly elevated in pre-diabetic and newly diagnosed type 2 diabetes patients, suggesting its potential utility as an early biomarker for insulin resistance and impaired glucose metabolism.
Should not yet change practice; leaves open whether apelin-36 is a useful early marker of insulin resistance.
Purpose: The aim of this study was to investigate the levels of parameters for glucose metabolism and cardiovascular risk factors and apelin-36 in patients grouped as having impaired fasting glucose(IFG), IFG and impaired glucose tolerance(IGT), newly diagnosed type 2 DM and the control group.Materials and Methods: Fifty-three women and twenty-seven men, totally eighty subjects were enrolled in this study. The patients were classified into four groups according to their oral glucose tolerance test (OGTT) results. Group1: Normoglycemic controls(n:20), Group2: subjects with IFG(n:20), Group3: combined IFG subjects which included both IFG and IGT patients(n:20), Group4: Newly diagnosed type 2 DM patients(n:20). Levels of glucose, lipids, HbA1c, fibrinogen, insulin, cortisol, serum apelin-36 and C-peptide were analyzed.Results: There was a statistically significant difference regarding the levels of apelin-36 between group 1 and the study groups 2, 3 and 4, respectively. Other parameters analyzed for glucose metabolism and cardiovascular risk factors such as fasting glucose, HbA1c, HOMA-IR, fibrinogen, insulin, cortisol, C-peptide, LDL-cholesterol, HDL-cholesterol, VLDL-cholesterol, triglycerides, total cholesterol were significantly higher in the study groups when compared to the control group.Conclusion: In the future serum apelin-36 levels can be used as an indicator for presenting the insulin resistance and impairment in glucose metabolism in the early periods.
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Serin et al. (2019) studied this question.
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