What question did this study set out to answer?

To review standard multimodal treatment paradigms for glioblastoma and evaluate novel cellular, molecular, and targeted delivery approaches designed to overcome therapeutic resistance.

May 1, 2006Expert Review of Anticancer Therapy

Present and potential future issues in glioblastoma treatment

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Authors

FLFlorence LefrancUniversité Libre de Bruxelles NSNiloufar SadeghiErasmus Hospital ICIsabelle CambyGlaxoSmithKline (Belgium)

Discussion

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Implication

Review outlines multimodal management challenges and treatment resistance in glioblastoma, highlighting the need for novel molecular therapies and local drug delivery systems.

Key Points

To review standard multimodal treatment paradigms for glioblastoma and evaluate novel cellular, molecular, and targeted delivery approaches designed to overcome therapeutic resistance.
Reviewed standard multimodal care regimens, including maximal surgical resection followed by concurrent and adjuvant temozolomide chemotherapy with radiotherapy.
Assessed diagnostic and surgical guidance technologies, including magnetic resonance imaging and metabolic profiling, alongside ongoing clinical trials testing novel molecular interventions.
Current standard multimodal therapy remains palliative, with tumors almost invariably recurring locally and disease progression typically occurring within 6 months.
Constitutive activation of signaling pathways in migrating glioma cells promotes intrinsic resistance to apoptosis induced by conventional chemotherapies.
Investigational strategies focus on overcoming drug resistance through localized delivery systems and molecular therapies targeted at active survival pathways.

Cite This Study

Lefranc et al. (2006) studied this question.

synapsesocial.com/papers/6a800293cf96de1eb9c85d43 https://doi.org/10.1586/14737140.6.5.719

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Implication

Review outlines multimodal management challenges and treatment resistance in glioblastoma, highlighting the need for novel molecular therapies and local drug delivery systems.

Present and potential future issues in glioblastoma treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

Present and potential future issues in glioblastoma treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

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