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November 24, 2009Science SignalingOpen Access

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

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Authors

CCChong ChenSichuan UniversityYLYu LiuUniversity of MichiganYLYang LiuBrigham Young University

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Chen et al. (2009) studied this question.

synapsesocial.com/papers/6a8017da1024bacc969289a6https://doi.org/10.1126/scisignal.2000559
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate1998 · 3,131 citations
  2. 2Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice1995 · 200 citations
  3. 3TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species2008 · 688 citations