What question did this study set out to answer?

To determine the prevalence and clinical consequences of occult sleep-disordered breathing in ambulatory patients receiving stable, optimal medical therapy for congestive heart failure.

April 1, 1995Annals of Internal Medicine

Occult Sleep-Disordered Breathing in Stable Congestive Heart Failure

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Authors

SJShahrokh Javaheri

Discussion

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Overview

Prospective longitudinal study demonstrates high rates of occult sleep apnea in stable heart failure, indicating potential worsening of cardiac dysfunction.

Key Points

To determine the prevalence and clinical consequences of occult sleep-disordered breathing in ambulatory patients receiving stable, optimal medical therapy for congestive heart failure.
Conducted a prospective, longitudinal study of N=42 ambulatory patients with stable congestive heart failure and left ventricular systolic dysfunction (LVEF ≤ 45%).
Evaluated patients in a sleep laboratory using overnight polysomnography, Holter monitoring, arterial blood gas analyses, and radionuclide ventriculography.
Sleep-disordered breathing (AHI > 20 episodes/h) occurred in 45% of patients (n=19/42; 95% CI, 30% to 60%) with a mean AHI of 44 ± 13 episodes/h (95% CI, 38 to 51 episodes/h).
Patients with AHI > 20 experienced significantly more arousals (24 ± 12 vs. 3 ± 3), greater time with SaO2 < 90% (23% ± 24% vs. 2% ± 4%), lower minimum sleep SaO2 (74% ± 13% vs. 87% ± 4%), lower LVEF (22% ± 9% vs. 30% ± 10%), and increased nocturnal ventricular arrhythmias.
Multivariate regression analysis identified left ventricular systolic dysfunction as an independent risk factor for sleep apnea in this population.

Cite This Study

Shahrokh Javaheri (1995) studied this question.

synapsesocial.com/papers/6a8019280190ac0812700e97 https://doi.org/10.7326/0003-4819-122-7-199504010-00002

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April 1, 1995Annals of Internal Medicine

Occult Sleep-Disordered Breathing in Stable Congestive Heart Failure

View Full Paper

Ask AI

Bookmark

Authors

SJShahrokh Javaheri

Discussion

Member takes

Overview

Prospective longitudinal study demonstrates high rates of occult sleep apnea in stable heart failure, indicating potential worsening of cardiac dysfunction.

Key Points

To determine the prevalence and clinical consequences of occult sleep-disordered breathing in ambulatory patients receiving stable, optimal medical therapy for congestive heart failure.
Conducted a prospective, longitudinal study of N=42 ambulatory patients with stable congestive heart failure and left ventricular systolic dysfunction (LVEF ≤ 45%).
Evaluated patients in a sleep laboratory using overnight polysomnography, Holter monitoring, arterial blood gas analyses, and radionuclide ventriculography.
Sleep-disordered breathing (AHI > 20 episodes/h) occurred in 45% of patients (n=19/42; 95% CI, 30% to 60%) with a mean AHI of 44 ± 13 episodes/h (95% CI, 38 to 51 episodes/h).
Patients with AHI > 20 experienced significantly more arousals (24 ± 12 vs. 3 ± 3), greater time with SaO2 < 90% (23% ± 24% vs. 2% ± 4%), lower minimum sleep SaO2 (74% ± 13% vs. 87% ± 4%), lower LVEF (22% ± 9% vs. 30% ± 10%), and increased nocturnal ventricular arrhythmias.
Multivariate regression analysis identified left ventricular systolic dysfunction as an independent risk factor for sleep apnea in this population.

Cite This Study

Shahrokh Javaheri (1995) studied this question.

synapsesocial.com/papers/6a8019280190ac0812700e97 https://doi.org/10.7326/0003-4819-122-7-199504010-00002

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